Timeline

Voting rights breakdown

Notice details

Beneficial owner

S.R. One, Limited

S.R. One Ltd (www.srone.com) GlaxoSmithKline's independent corporate healthcare venture capital fund. S.R. One is the whollyowned subsidiary of SmkthKline Beecham Corp.; both are located at One Franklin Plaza, 200 N. 16th Street, Philadelphia, PA 18428 USA. The contact person at S.R. One is Russell Greig. SmithKline Beecham Corp is a wholly-owned subsidiary of GlaxoSmithKline Holdings (Americas) Inc., located at Wilmington Trust SP Services Inc. 1105 N. Market St., Suite 1300, Wilmington Delaware 19801 USA and a wholly-owned subsidiary of Setfirst Ltd. Setfirst Ltd* is 50.1% owned by SmithKline Beecham Holdings (U.K.) Ltd and 49.9% owned by Glaxo Wellcome Investments BV. GlaxoWellcome Investments BV (located at Huis ter Heideweg 62, 3705 LZ, Zeist, Netherlands) is a wholly-owned subsidiary of Glaxo Wellcome Holdings Ltd. Glaxo Welcome Holdings Ltd is 83.34% owned by Wellcome Ltd and 16.66% owned by Glaxo Group Ltd. Wellcome Ltd is a subsidiary of GlaxoSmithKline Finance plc. Glaxo Group Ltd (located at Glaxo Wellcome House, Berkeley Avenue, Greenford, Middlesex, UB6 0NN, U.K.) is a wholly-owned subsidiary of GlaxoSmithKline Finance plc. SmithKline Beecham Holdings (U.K.) is a wholly-owned subsidiary of Smithkline Beecham Overseas Ltd, which in turn, is a wholly-owned subsidiary of SmithKline Beecham plc. SmithKline Beecham is a wholly owned subsidiary of GlaxoSmithKline Finance plc, a wholly-owned subsidiary of GlaxoSmithKline Holdings Ltd. GlaxoSmithKline Holdings is a wholly-owned subsidiary of GlaxoSmithKline plc. As a result, GlaxoSmithKline plc is the ultimate beneficial owner of the shares. *Unless otherwise indicated, the entities listed in the above paragraph are located at 980 Great West Road, Brentford, Middlesex, TW8 9GS, U.K.