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Beneficial owner

Amgen Inc

Bond conversion into equity. The restructuring of the convertible bonds announced by the Company has been effected. The percentage indicated below is based on the increased share capital of the Company (as per the entry in the commercial register). Warrants are directly held by Amgen Investments Ltd.,Canon's Court, 22 Victoria Street, Hamilton HM 12, Bermuda, which is owned 100% by Amgen Manufacturing Ltd.,Canon's Court, 22 Victoria Street, Hamilton HM 12, Bermuda. Amgen Manufacturing Ltd. is owned 100% by Amgen Technology Ltd., Canon's Court, 22 Victoria Street, Hamilton HM 12, Bermuda, which is owned 10% by Amgen International LLC, 2711 Centerville Road, Suite 400 Wilmington, DE 19808, USA, and 90% by Amgen Inc., 2711 Centerville Road, Wilmington, DE 19808, USA, a public company listed on the NASDAQ. Amgen Inc. owns 100% of Amgen International LLC.